In medicine, men still dominate the field—both as doctors who conduct research and provide care, and as patients who are the subjects of research. We want to do our part to change that.
Most therapies and medications available on the market are tested primarily on men, which can have dangerous consequences for women. Even in the field of women’s health, women’s individual biology is rarely taken into account; instead, the standard 28-day cycle with ovulation on day 14 is assumed.
With the OvulaRing Method: “Cyclofertilography” We are conducting various studies with women based on the biomarker core body temperature. Our vision: a paradigm shift in medical diagnostics, so that individual biology can finally serve as the foundation for evidence-based treatment decisions.
2013–2018: Continuous basal body temperature measurement as a supplement to cycle monitoring in women seeking to conceive.
Goeckenjan, Maren; Schiwek, Esther; Wimberger, Pauline (2020) Continuous Body Temperature Monitoring to Improve the Diagnosis of Female Infertility
Ovulatory dysfunction is a major cause of female infertility. We evaluated the use of continuous body temperature monitoring with a vaginal biosensor to improve standard diagnostic procedures for determining ovulatory dysfunction.
2012–2013: A monocentric study for the scientific evaluation of circadian temperature patterns in the female menstrual cycle using the OvulaRing cycle tracking system
1999–2007 Clinical study and trial to evaluate the efficacy and tolerability of a telemetric ring pessary for measuring a woman’s basal body temperature
Alexander H. In: Ärzteblatt Sachsen; 12: 539–542. (2015) The cyclofertilogram for accurate cycle and fertility diagnosis.
More and more women are taking an interest in their menstrual cycles and cycle health. For women of reproductive age in particular, the menstrual cycle plays a central role—not only when it comes to trying to conceive, but also when seeking hormone-free contraception.
Saba Shakalio, Strength and Conditioning Coach at St. Pauli & Cologne Sport University; 2021–2022;
Status: Analysis in progress
This study is the first to test the sprint endurance of Bundesliga women’s water polo players during different phases of the menstrual cycle. Understanding performance fluctuations within a cycle helps us with training periodization in competitive sports, so that we can cycle-based training plan can improve the athletes’ performance without jeopardizing their health.
VivoSensMedical GmbH, Contact: Laura Matthes
Users reported when they were vaccinated. If they had recorded at least three comparison cycles, we checked whether the cycle characteristics had changed during the “vaccination cycle.” Regarding cycle length, it is already apparent that shortening was virtually nonexistent. Lengthening occurs at a frequency that would also be expected in other cycles coinciding with physiological stress (fever, medication, fasting, separation).
Although the vaccinations were administered in equal proportions during the first and second halves of the cycle, in cases where the cycle was extended, 75% of the vaccinations were administered during the first phase of the cycle. This suggests that the cycle rhythm is less susceptible to disruption when vaccinations are administered during the second phase of the cycle.
We are currently asking our past and current users about their children’s due dates. Gynecologists typically calculate the due date based on the first day of the last menstrual period. The first day of the last menstrual period plus 14 days is usually assumed to be the date of conception. Of course, this is only accurate if ovulation occurred on that day. However, this is rarely the case. Nevertheless, the due date is calculated this way. All subsequent examinations of the fetus and the assessment of whether it is developing in line with the gestational week are based on this method of calculating conception.
However, conception often occurred later. This means that when ovulation occurs later, the fetus is consistently assessed by gynecologists as “not developed enough”—to the point of being classified as a high-risk pregnancy. The stress this causes in expectant mothers, which may actually lead to complications, is unnecessary if ovulation has been detected with OvulaRing.
In this study, we aim to compare how closely the due date calculated by gynecologists or OvulaRing matches the actual date of birth in cases of natural childbirth. To do this, we really need as many participants as possible.
This issue is particularly important to us, as no one has researched this highly relevant topic yet. Did you become pregnant while using OvulaRing? Help us address this issue.
In general, users who use the OvulaRing to try to conceive show greater variability in their cycle characteristics. We assume that women who use the OvulaRing for contraception are more representative of the general population.
In 2022, we will publish statistics on cycle length, ovulation day, luteal phase length, and anovulation frequency by usage type, age, and BMI.
This research topic has yet to be addressed. Since we currently lack the capacity to do so, we welcome inquiries regarding potential collaborations. We have already collected all the necessary data. Ambitious master’s students with skills in statistical programming are also encouraged to contact us if they are interested.
Ansprechpartnerin: Laura Matthes, Research and Development; info@vivosensmedical.com
This research topic has yet to be addressed. Since we currently lack the capacity to do so, we welcome inquiries regarding potential collaborations. Inquiries from researchers in the fields of rheumatology and multiple sclerosis are warmly welcomed.
Contact person: Laura Matthes, Research and Development; info@vivosensmedical.com
The data recorded with OvulaRing provides you with entirely new insights into the processes of the female cycle in gynecology and related fields. The OvulaRing method is already being used successfully by doctors, alternative practitioners, midwives, trainers, and in scientific research.
By researching core body temperature as a biomarker, VivoSensMedical has developed a unique method for real-time gynecological and endocrinological cycle diagnostics and has brought it to market in the form of the Cyclofertilogram and OvulaRing for both users and physicians. The results are comparable to daily blood hormone level measurements or daily vaginal ultrasounds. In proprietary and independent medical studies conducted at the University Women’s Clinics in Leipzig and Dresden, it was found, among other things, that nearly 70% of women ovulated outside the expected time (day 14) but still exhibited a healthy biphasic cycle. These new findings demonstrate the variability of cycles and show that every woman has an individual fertility pattern. (Alexander 2015 / Regidor 2017 / Göckenjan 2020)
Core body temperature, as an indirect endocrinological biomarker, can be applied in many areas of gynecology. We are currently conducting research, among other things, to further improve individualized cycle diagnostics by identifying the day of ovulation and the fertile window to optimize conception, for use in the treatment of in vitro fertilization (IVF), supporting safe, hormone-free contraception, and diagnosing risks during pregnancy to, for example, detect a threatened miscarriage and other pregnancy-related conditions at an early stage.
Every person has an individual internal clock that plays a key role in the success of drug therapies, among other things. Depending on this internal clock, medications are metabolized differently in each patient at different times. However, this factor is currently rarely taken into account when prescribing medications for patients. Above all, there is a lack of diagnostic methods for determining an individual’s circadian rhythm. The vision: More targeted administration of medications in accordance with the biorhythm to increase treatment success and reduce side effects, particularly in therapeutic areas with high medication requirements, such as oncology.
In a 2017 study (Eckhart et al. 2017)* conducted by VivoSensMedical in collaboration with the Institute of Chronobiology at Goethe University in Frankfurt am Main, the diurnal core body temperature rhythm in women was investigated for the first time under “real-life” conditions.
Since 2016, VivoSensMedical has been involved in a clinical study in collaboration with the Max Planck Institute for Cognitive and Neural Sciences, which is investigating the influence of the female menstrual cycle on brain structure. The research results will show whether and to what extent brain structure changes during the various phases of the menstrual cycle: menstruation, the follicular phase, the fertile window with ovulation, and the luteal phase.
Since 2019, VivoSensMedical has also been conducting research in the field of menopause. The clinical study on “The Effect of Progesterone Replacement During the Luteal Phase on Resting Energy Expenditure During the Menopausal Transition” is being conducted in collaboration with the University Women’s Hospital in Bern.
More than 2.5 million people worldwide suffer from multiple sclerosis (MS International Federation), and women are now three times more likely to develop the disease than men (Ärztezeitung online, October 30, 2017). There are currently no research studies in the scientific literature analyzing core body temperature patterns in autoimmune diseases. In everyday clinical practice, there is a lack of diagnostic methods for the early detection of disease relapses that would allow therapies to be tailored to the individual disease progression of patients with autoimmune diseases. The identification of relapses in autoimmune diseases currently occurs too late—namely, only after a relapse has occurred—and involves an enormous diagnostic effort (e.g., MRI for MS). Every autoimmune disease is accompanied by inflammatory processes that correlate with changes in core body temperature. Under certain circumstances, these processes are reflected in an individual temperature pattern that needs to be identified. For this reason, VivoSensMedical is currently planning a study on “Core Body Temperature and Autoimmune Flare-Ups in Women Seeking Pregnancy with Multiple Sclerosis or Rheumatic Diseases.”
Can you imagine how OvulaRing data might help answer a scientific question that’s been on your mind? Get in touch with us—we’re always on the lookout for new project ideas!
We are committed to advancing research. However, please understand that we cannot respond to every inquiry immediately.
Scientific research is our passion, to improve the quality of diagnostics in women’s health over the long term!
Take control of your fertility now and get to know your cycle better. Whether you’re trying to get pregnant, looking for natural birth control, or simply want to understand how your cycle works.
Starting at €44 per month
* Gnoth et al. 2003 zitiert Eckhart D et al. 2017. Dynamics of core body temperature cycles in longterm measurements under real life conditions in women, Chronobiology International, DOI, 10.1080/07420528.2017.127594
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